Dynamic modeling of complex biological systems: a link between metabolic and macroscopic description.
نویسندگان
چکیده
In this study, a class of dynamic models based on metabolic reaction pathways is analyzed, showing that systems with complex intracellular reaction networks can be represented by macroscopic reactions relating extracellular components only. Based on rigorous assumptions, the model reduction procedure is systematic and allows an equivalent 'input-output' representation of the system to be derived. The procedure is illustrated with a few examples.
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ورودعنوان ژورنال:
- Mathematical biosciences
دوره 193 1 شماره
صفحات -
تاریخ انتشار 2005